Retrospective comparison of convalescent plasma with continuing high‐dose methylprednisolone treatment in SARS patients

YOY Soo, Y Cheng, R Wong, DS Hui… - Clinical microbiology …, 2004 - Wiley Online Library
YOY Soo, Y Cheng, R Wong, DS Hui, CK Lee, KKS Tsang, MHL Ng, P Chan, G Cheng…
Clinical microbiology and infection, 2004Wiley Online Library
Abstract Treatment of severe acute respiratory syndrome (SARS) is experimental, and the
effectiveness of ribavirin–steroid therapy is unclear. Forty SARS patients with progressive
disease after ribavirin treatment and 1.5 g of pulsed methylprednisolone were given either
convalescent plasma (n= 19) or further pulsed methylprednisolone (n= 21) in a retrospective
non‐randomised study. Good clinical outcome was defined as discharge by day 22
following the onset of symptoms. Convalescent plasma was obtained from recovered …
Abstract
Treatment of severe acute respiratory syndrome (SARS) is experimental, and the effectiveness of ribavirin–steroid therapy is unclear. Forty SARS patients with progressive disease after ribavirin treatment and 1.5 g of pulsed methylprednisolone were given either convalescent plasma (n = 19) or further pulsed methylprednisolone (n = 21) in a retrospective non‐randomised study. Good clinical outcome was defined as discharge by day 22 following the onset of symptoms. Convalescent plasma was obtained from recovered patients after informed consent. Patients in the plasma group had a shorter hospital stay (p 0.001) and lower mortality (p 0.049) than the comparator group. No immediate adverse effects were observed following plasma infusion.
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