[PDF][PDF] OLFR734 mediates glucose metabolism as a receptor of asprosin

E Li, H Shan, L Chen, A Long, Y Zhang, Y Liu, L Jia… - Cell metabolism, 2019 - cell.com
E Li, H Shan, L Chen, A Long, Y Zhang, Y Liu, L Jia, F Wei, J Han, T Li, X Liu, H Deng…
Cell metabolism, 2019cell.com
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and
stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an
unknown G protein-coupled receptor (GPCR). However, the bona fide receptor of Asprosin
is unclear. Here, we have identified that the olfactory receptor OLFR734 acts as a receptor of
Asprosin to modulate hepatic glucose production. Olfr734 knockout mice show a blunted
response to Asprosin, including attenuated cAMP levels and hepatic glucose production …
Summary
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). However, the bona fide receptor of Asprosin is unclear. Here, we have identified that the olfactory receptor OLFR734 acts as a receptor of Asprosin to modulate hepatic glucose production. Olfr734 knockout mice show a blunted response to Asprosin, including attenuated cAMP levels and hepatic glucose production, and improved insulin sensitivity. As Olfr734 deficiency dramatically attenuates both fasting and high-fat-diet-induced glucose production, our results demonstrate a critical role of OLFR734 as a receptor of Asprosin to maintain glucose homeostasis during fasting and in obesity.
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