Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across species

KA Zimmerman, MR Bentley, JM Lever… - Journal of the …, 2019 - journals.lww.com
Background Resident macrophages regulate homeostatic and disease processes in
multiple tissues, including the kidney. Despite having well defined markers to identify these
cells in mice, technical limitations have prevented identification of a similar cell type across
species. The inability to identify resident macrophage populations across species hinders
the translation of data obtained from animal model to human patients. Methods As an entry
point to determine novel markers that could identify resident macrophages across species …