Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy
Q Cao, Y Wang, XM Wang, J Lu, VWS Lee… - Journal of the …, 2015 - journals.lww.com
Conventional markers of macrophages (Mфs) and dendritic cells (DCs) lack specificity and
often overlap, leading to confusion and controversy regarding the precise function of these
cells in kidney and other diseases. This study aimed to identify the phenotype and function
of renal mononuclear phagocytes (rMPs) expressing key markers of both Mфs and DCs.
F4/80+ CD11c+ cells accounted for 45% of total rMPs in normal kidneys and in those from
mice with Adriamycin nephropathy (AN). Despite expression of the DC marker CD11c, these …
often overlap, leading to confusion and controversy regarding the precise function of these
cells in kidney and other diseases. This study aimed to identify the phenotype and function
of renal mononuclear phagocytes (rMPs) expressing key markers of both Mфs and DCs.
F4/80+ CD11c+ cells accounted for 45% of total rMPs in normal kidneys and in those from
mice with Adriamycin nephropathy (AN). Despite expression of the DC marker CD11c, these …