[HTML][HTML] Graft-versus-leukemia effect following hematopoietic stem cell transplantation for leukemia
AM Dickinson, J Norden, S Li, I Hromadnikova… - Frontiers in …, 2017 - frontiersin.org
AM Dickinson, J Norden, S Li, I Hromadnikova, C Schmid, H Schmetzer, H Jochem-Kolb
Frontiers in immunology, 2017•frontiersin.orgThe success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia
effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL
effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T
cells, and activated dendritic cells of leukemic origin. The history and further application of
this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia
effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL
effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T
cells, and activated dendritic cells of leukemic origin. The history and further application of
this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
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