Context Cognitive impairment and functional disability are major determinants of caregiving
needs and societal health care costs. Although the incidence of severe sepsis is high and
increasing, the magnitude of patients' long-term cognitive and functional limitations after
sepsis is unknown. Objective To determine the change in cognitive impairment and physical
functioning among patients who survive severe sepsis, controlling for their presepsis
functioning. Design, Setting, and Patients A prospective cohort involving 1194 patients with …