[HTML][HTML] Serotonin (5-hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle
E Hajduch, F Rencurel, A Balendran, IH Batty… - Journal of Biological …, 1999 - ASBMB
In this study we show that serotonin (5-hydroxytryptamine (5-HT)) causes a rapid stimulation
in glucose uptake by∼ 50% in both L6 myotubes and isolated rat skeletal muscle. This
activation is mediated via the 5-HT 2A receptor, which is expressed in L6, rat, and human
skeletal muscle. In L6 cells, expression of the 5-HT 2A receptor is developmentally regulated
based on the finding that receptor abundance increases by over 3-fold during differentiation
from myoblasts to myotubes. Stimulation of the 5-HT 2A receptor using methylserotonin (m …
in glucose uptake by∼ 50% in both L6 myotubes and isolated rat skeletal muscle. This
activation is mediated via the 5-HT 2A receptor, which is expressed in L6, rat, and human
skeletal muscle. In L6 cells, expression of the 5-HT 2A receptor is developmentally regulated
based on the finding that receptor abundance increases by over 3-fold during differentiation
from myoblasts to myotubes. Stimulation of the 5-HT 2A receptor using methylserotonin (m …