Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy
NR Bolo, Y Hodé, JF Nédélec, E Lainé… - …, 2000 - Elsevier
This investigation of fluvoxamine and fluoxetine-norfluoxetine distributions in vivo at steady-
state and of quantitative kinetics in brain and plasma after drug therapy interruption was
performed by fluorine nuclear magnetic resonance spectroscopy (19F MRS), spectroscopic
imaging (MRSI), and plasma HPLC on 12 subjects treated for depression. MRSI suggests a
homogeneous distribution of 19F MRS visible fluvoxamine mainly in brain. Fluvoxamine
steady-state brain concentrations (12±5 μM; n= 13) and brain-to-plasma concentration ratios …
state and of quantitative kinetics in brain and plasma after drug therapy interruption was
performed by fluorine nuclear magnetic resonance spectroscopy (19F MRS), spectroscopic
imaging (MRSI), and plasma HPLC on 12 subjects treated for depression. MRSI suggests a
homogeneous distribution of 19F MRS visible fluvoxamine mainly in brain. Fluvoxamine
steady-state brain concentrations (12±5 μM; n= 13) and brain-to-plasma concentration ratios …