[HTML][HTML] Persistence of mucosal T-cell responses to herpes simplex virus type 2 in the female genital tract
CM Posavad, L Zhao, DE Mueller, CE Stevens… - Mucosal …, 2015 - Elsevier
Relatively little is known about the human T-cell response to herpes simplex virus type 2
(HSV-2) in the female genital tract, a major site of heterosexual HSV-2 acquisition,
transmission, and reactivation. In order to understand the role of local mucosal immunity in
HSV-2 infection, T-cell lines were expanded from serial cervical cytobrush samples from 30
HSV-2-infected women and examined for reactivity to HSV-2. Approximately 3% of the CD3+
T cells isolated from the cervix were HSV-2 specific and of these, a median of 91.3% were …
(HSV-2) in the female genital tract, a major site of heterosexual HSV-2 acquisition,
transmission, and reactivation. In order to understand the role of local mucosal immunity in
HSV-2 infection, T-cell lines were expanded from serial cervical cytobrush samples from 30
HSV-2-infected women and examined for reactivity to HSV-2. Approximately 3% of the CD3+
T cells isolated from the cervix were HSV-2 specific and of these, a median of 91.3% were …