[HTML][HTML] Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity
W Zha, ML Edin, KC Vendrov, RN Schuck, FB Lih… - Journal of lipid …, 2014 - ASBMB
Adipogenesis plays a critical role in the initiation and progression of obesity. Although
cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a
potential therapeutic target for cardiometabolic disease, the functional contribution of EETs
to adipogenesis and the pathogenesis of obesity remain poorly understood. Our studies
demonstrated that induction of adipogenesis in differentiated 3T3-L1 cells (in vitro) and
obesity-associated adipose expansion in high-fat diet (HFD)-fed mice (in vivo) significantly …
cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a
potential therapeutic target for cardiometabolic disease, the functional contribution of EETs
to adipogenesis and the pathogenesis of obesity remain poorly understood. Our studies
demonstrated that induction of adipogenesis in differentiated 3T3-L1 cells (in vitro) and
obesity-associated adipose expansion in high-fat diet (HFD)-fed mice (in vivo) significantly …