[HTML][HTML] Peptidoglycan induces nuclear factor-κB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages
BC Chen, YS Chang, JC Kang, MJ Hsu… - Journal of Biological …, 2004 - ASBMB
In this study, we investigated the signaling pathway involved in cyclooxygenase-2 (COX-2)
expression caused by peptidoglycan (PGN), a cell wall component of the Gram-positive
bacterium Staphylococcus aureus, in RAW 264.7 macrophages. PGN caused dose-and time-
dependent increases in COX-2 expression, which was attenuated by a Ras inhibitor
(manumycin A), a Raf-1 inhibitor (GW 5074), and an MEK inhibitor (PD 098059). Treatment
of RAW 264.7 macrophages with PGN caused time-dependent activations of Ras, Raf-1 …
expression caused by peptidoglycan (PGN), a cell wall component of the Gram-positive
bacterium Staphylococcus aureus, in RAW 264.7 macrophages. PGN caused dose-and time-
dependent increases in COX-2 expression, which was attenuated by a Ras inhibitor
(manumycin A), a Raf-1 inhibitor (GW 5074), and an MEK inhibitor (PD 098059). Treatment
of RAW 264.7 macrophages with PGN caused time-dependent activations of Ras, Raf-1 …