Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of
arachidonic acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be
further metabolized by soluble epoxide hydrolase to the corresponding
dihydroxyeicosatrienoic acids. Evidence exists that these metabolites affect renal function
and, in particular, blood pressure regulation. To examine this possibility, blood pressure and
renal arachidonic acid metabolism were examined in mice with a targeted disruption of the …