[HTML][HTML] Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy
JM Caviglia, C Gayet, T Ota, A Hernandez-Ono… - Journal of lipid …, 2011 - ASBMB
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of
apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits
secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid
(PA) induces ER stress, but its effects on apoB100 secretion are unclear. Docosahexaenoic
acid (DHA) inhibits apoB100 secretion, but its effects on ER stress have not been studied.
We compared the effects of each of these fatty acids on ER stress and apoB100 secretion in …
apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits
secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid
(PA) induces ER stress, but its effects on apoB100 secretion are unclear. Docosahexaenoic
acid (DHA) inhibits apoB100 secretion, but its effects on ER stress have not been studied.
We compared the effects of each of these fatty acids on ER stress and apoB100 secretion in …