Nampt: linking NAD biology, metabolism and cancer

A Garten, S Petzold, A Körner, S Imai… - Trends in endocrinology & …, 2009 - cell.com
A Garten, S Petzold, A Körner, S Imai, W Kiess
Trends in endocrinology & metabolism, 2009cell.com
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide
mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate.
Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially
claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in
several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic
enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and …
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic β-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.
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