Cancer metabolism: facts, fantasy, and fiction
XL Zu, M Guppy - Biochemical and biophysical research communications, 2004 - Elsevier
XL Zu, M Guppy
Biochemical and biophysical research communications, 2004•ElsevierThe concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This
perception has since become the rationale that drives a considerable proportion of basic
research on cancer, and it influences the current strategies for the diagnosis, monitoring,
and treatment of cancer. Here we review the data from the last 40 years on this issue. We
conclude that there is no evidence that cancer cells are inherently glycolytic, but that some
tumours might indeed be glycolytic in vivo as a result of their hypoxic environment.
perception has since become the rationale that drives a considerable proportion of basic
research on cancer, and it influences the current strategies for the diagnosis, monitoring,
and treatment of cancer. Here we review the data from the last 40 years on this issue. We
conclude that there is no evidence that cancer cells are inherently glycolytic, but that some
tumours might indeed be glycolytic in vivo as a result of their hypoxic environment.
The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data from the last 40 years on this issue. We conclude that there is no evidence that cancer cells are inherently glycolytic, but that some tumours might indeed be glycolytic in vivo as a result of their hypoxic environment.
Elsevier