Neutrophils are deprived of proliferative capacity and have a tightly controlled lifespan to
avoid their persistence at the site of injury. We have recently described that the proliferating
cell nuclear antigen (PCNA), a nuclear factor involved in DNA replication and repair of
proliferating cells, is a key regulator of neutrophil survival. In neutrophils, PCNA was
localized exclusively in the cytoplasm due to its nuclear-to-cytoplasmic relocalization during
granulocytic differentiation. We showed here that leptomycin B, an inhibitor of the …