[HTML][HTML] Scap is required for sterol synthesis and crypt growth in intestinal mucosa [S]
MR McFarlane, MJ Cantoria, AG Linden… - Journal of lipid …, 2015 - ASBMB
SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein
required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs),
which activate the transcription of genes in sterol and fatty acid biosynthesis. Liver-specific
loss of Scap is well tolerated; hepatic synthesis of sterols and fatty acids is reduced, but mice
are otherwise healthy. To determine whether Scap loss is tolerated in the intestine, we
generated a mouse model (Vil-Scap−) in which tamoxifen-inducible Cre-ER T2, a fusion …
required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs),
which activate the transcription of genes in sterol and fatty acid biosynthesis. Liver-specific
loss of Scap is well tolerated; hepatic synthesis of sterols and fatty acids is reduced, but mice
are otherwise healthy. To determine whether Scap loss is tolerated in the intestine, we
generated a mouse model (Vil-Scap−) in which tamoxifen-inducible Cre-ER T2, a fusion …