APOL1 localization in normal kidney and nondiabetic kidney disease
SM Madhavan, JF O'Toole… - Journal of the …, 2011 - journals.lww.com
In patients of African ancestry, genetic variants in APOL1, which encodes apolipoprotein L1,
associate with the nondiabetic kidney diseases, focal segmental glomerulosclerosis (FSGS),
HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. Understanding the
renal localization of APOL1 may provide clues that will ultimately help elucidate the
mechanisms by which APOL1 variants promote nephropathy. Here, we used
immunohistology to examine APOL1 localization in normal human kidney sections and in …
associate with the nondiabetic kidney diseases, focal segmental glomerulosclerosis (FSGS),
HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. Understanding the
renal localization of APOL1 may provide clues that will ultimately help elucidate the
mechanisms by which APOL1 variants promote nephropathy. Here, we used
immunohistology to examine APOL1 localization in normal human kidney sections and in …