[HTML][HTML] Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1
MH Lee, S Atkinson, G Murphy - Journal of biological chemistry, 2007 - ASBMB
Tissue inhibitor of metalloproteinases (TIMPs) are the endogenous inhibitors of the zinc-
dependent endopeptidases of the matrix metalloproteinase families. There are four
mammalian TIMPs (TIMP-1 to-4) but only TIMP-3 is sequestered to the extracellular matrix
(ECM). The molecular basis for the TIMP-3: ECM association has never been fully
investigated until now. In this report, we identify the unique amino acid configuration that
constitutes the basis of the ECM binding motif in TIMP-3. By systematically exchanging the …
dependent endopeptidases of the matrix metalloproteinase families. There are four
mammalian TIMPs (TIMP-1 to-4) but only TIMP-3 is sequestered to the extracellular matrix
(ECM). The molecular basis for the TIMP-3: ECM association has never been fully
investigated until now. In this report, we identify the unique amino acid configuration that
constitutes the basis of the ECM binding motif in TIMP-3. By systematically exchanging the …