[HTML][HTML] High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation …
L Zhang, SL Lim, H Du, M Zhang, I Kozak… - Journal of Biological …, 2012 - ASBMB
Genome-wide association study (GWAS) has identified genetic variants in the promoter
region of the high temperature requirement factor A1 (HTRA1) gene associated with age-
related macular degeneration (AMD). As a secreted serine protease, HTRA1 has been
reported to interact with members of the transforming growth factor-β (TGF-β) family and
regulate their signaling pathways. Growth differentiation factor 6 (GDF6), a member of the
TGF-β family, is involved in ectoderm patterning and eye development. Mutations in GDF6 …
region of the high temperature requirement factor A1 (HTRA1) gene associated with age-
related macular degeneration (AMD). As a secreted serine protease, HTRA1 has been
reported to interact with members of the transforming growth factor-β (TGF-β) family and
regulate their signaling pathways. Growth differentiation factor 6 (GDF6), a member of the
TGF-β family, is involved in ectoderm patterning and eye development. Mutations in GDF6 …