[HTML][HTML] The metabolic modulator PGC-1α in cancer
F Bost, L Kaminski - American journal of cancer research, 2019 - ncbi.nlm.nih.gov
F Bost, L Kaminski
American journal of cancer research, 2019•ncbi.nlm.nih.govThe peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a
central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative
metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer
cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles
have shown that PGC-1α expression is altered in tumors and metastasis in relation to
modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target …
central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative
metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer
cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles
have shown that PGC-1α expression is altered in tumors and metastasis in relation to
modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target …
Abstract
The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles have shown that PGC-1α expression is altered in tumors and metastasis in relation to modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target and a biomarker of the advanced form of cancer will be summarized in this review.
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