Background Hypertriglyceridemia (HTG) is a complex trait defined by elevated plasma
triglyceride levels. Genetic determinants of HTG have so far been examined in a piecemeal
manner; understanding of its molecular basis, both monogenic and polygenic, is thus
incomplete. Objective The objective of this study was to characterize genetic profiles of
patients with severe HTG, and quantify the genetic determinants and molecular contributors.
Methods We concurrently assessed rare and common variants in two independent cohorts …