cAMP responsive element-binding protein H (CREBH) is an endoplasmic reticulum (ER)
anchored transcription factor that is highly expressed in the liver and small intestine and
implicated in nutrient metabolism and proinflammatory response. ApoA-IV is a glycoprotein
secreted primarily by the intestine and to a lesser degree by the liver. ApoA-IV expression is
suppressed in CREBH-deficient mice and strongly induced by enforced expression of the
constitutively active form of CREBH, indicating that CREBH is the major transcription factor …