[HTML][HTML] mTOR· RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

RC Hresko, M Mueckler - Journal of Biological Chemistry, 2005 - ASBMB
The insulin-signaling pathway leading to the activation of Akt/protein kinase B has been well
characterized except for a single step, the phosphorylation of Akt at Ser-473. Double-
stranded DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM)
gene product, integrin-linked kinase (ILK), protein kinase Cα (PKCα), and mammalian target
of rapamycin (mTOR), when complexed to rapamycin-insensitive companion of mTOR
(RICTOR), have all been identified as playing a critical role in Akt Ser-473 phosphorylation …