[HTML][HTML] Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein …
R Dettori, S Sonzogni, L Meyer… - Journal of biological …, 2009 - ASBMB
The members of the AGC kinase family frequently exhibit three conserved phosphorylation
sites: the activation loop, the hydrophobic motif (HM), and the zipper (Z)/turn-motif (TM)
phosphorylation site. 3-Phosphoinositide-dependent protein kinase 1 (PDK1)
phosphorylates the activation loop of numerous AGC kinases, including the protein kinase C-
related protein kinases (PRKs). Here we studied the docking interaction between PDK1 and
PRK2 and analyzed the mechanisms that regulate this interaction. In vivo labeling of …
sites: the activation loop, the hydrophobic motif (HM), and the zipper (Z)/turn-motif (TM)
phosphorylation site. 3-Phosphoinositide-dependent protein kinase 1 (PDK1)
phosphorylates the activation loop of numerous AGC kinases, including the protein kinase C-
related protein kinases (PRKs). Here we studied the docking interaction between PDK1 and
PRK2 and analyzed the mechanisms that regulate this interaction. In vivo labeling of …