[HTML][HTML] PKC and PKN in heart disease
V Marrocco, J Bogomolovas, E Ehler… - Journal of molecular …, 2019 - ncbi.nlm.nih.gov
Journal of molecular and cellular cardiology, 2019•ncbi.nlm.nih.gov
The protein kinase C (PKC) and closely related protein kinase N (PKN) families of
serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC
subfamily of protein kinases that also include the cAMP dependent protein kinase (PKA),
protein kinase B (PKB/AKT), protein kinase G (PKG) and the ribosomal protein S6 kinase
(S6K). Involvement of PKC family members in heart disease has been well documented over
the years, as their activity and levels are mis-regulated in several pathological heart …
serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC
subfamily of protein kinases that also include the cAMP dependent protein kinase (PKA),
protein kinase B (PKB/AKT), protein kinase G (PKG) and the ribosomal protein S6 kinase
(S6K). Involvement of PKC family members in heart disease has been well documented over
the years, as their activity and levels are mis-regulated in several pathological heart …
Abstract
The protein kinase C (PKC) and closely related protein kinase N (PKN) families of serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC subfamily of protein kinases that also include the cAMP dependent protein kinase (PKA), protein kinase B (PKB/AKT), protein kinase G (PKG) and the ribosomal protein S6 kinase (S6K). Involvement of PKC family members in heart disease has been well documented over the years, as their activity and levels are mis-regulated in several pathological heart conditions, such as ischemia, diabetic cardiomyopathy, as well as hypertrophic or dilated cardiomyopathy.
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