Accurate estimation of the contrast transfer function (CTF) is critical for a near-atomic
resolution cryo electron microscopy (cryoEM) reconstruction. Here, a GPU-accelerated
computer program, Gctf, for accurate and robust, real-time CTF determination is presented.
The main target of Gctf is to maximize the cross-correlation of a simulated CTF with the
logarithmic amplitude spectra (LAS) of observed micrographs after background subtraction.
Novel approaches in Gctf improve both speed and accuracy. In addition to GPU acceleration …