[HTML][HTML] Gangliosides as high affinity receptors for tetanus neurotoxin
C Chen, Z Fu, JJP Kim, JT Barbieri… - Journal of biological …, 2009 - ASBMB
Tetanus neurotoxin (TeNT) is an exotoxin produced by Clostridium tetani that causes
paralytic death to hundreds of thousands of humans annually. TeNT cleaves vesicle-
associated membrane protein-2, which inhibits neurotransmitter release in the central
nervous system to elicit spastic paralysis, but the molecular basis for TeNT entry into
neurons remains unclear. TeNT is a∼ 150-kDa protein that has AB structure-function
properties; the A domain is a zinc metalloprotease, and the B domain encodes a …
paralytic death to hundreds of thousands of humans annually. TeNT cleaves vesicle-
associated membrane protein-2, which inhibits neurotransmitter release in the central
nervous system to elicit spastic paralysis, but the molecular basis for TeNT entry into
neurons remains unclear. TeNT is a∼ 150-kDa protein that has AB structure-function
properties; the A domain is a zinc metalloprotease, and the B domain encodes a …