The multicellular complexity of peripheral nerve regeneration
AL Cattin, AC Lloyd - Current opinion in neurobiology, 2016 - Elsevier
AL Cattin, AC Lloyd
Current opinion in neurobiology, 2016•ElsevierHighlights•Regeneration of the PNS is a complex, highly coordinated, multicellular process.•
Macrophages have multiple roles to condition the environment for axonal
regrowth.•Schwann cells guide and nurture regrowing axons back to their targets.•Polarised
blood vessels direct Schwann cell migration across the region of injury.Peripheral nerves
show a remarkable ability to regenerate following a transection injury. Downstream of the
cut, the axons degenerate and so to regenerate the nerve, the severed axons need to …
Macrophages have multiple roles to condition the environment for axonal
regrowth.•Schwann cells guide and nurture regrowing axons back to their targets.•Polarised
blood vessels direct Schwann cell migration across the region of injury.Peripheral nerves
show a remarkable ability to regenerate following a transection injury. Downstream of the
cut, the axons degenerate and so to regenerate the nerve, the severed axons need to …
Highlights
- Regeneration of the PNS is a complex, highly coordinated, multicellular process.
- Macrophages have multiple roles to condition the environment for axonal regrowth.
- Schwann cells guide and nurture regrowing axons back to their targets.
- Polarised blood vessels direct Schwann cell migration across the region of injury.
Peripheral nerves show a remarkable ability to regenerate following a transection injury. Downstream of the cut, the axons degenerate and so to regenerate the nerve, the severed axons need to regrow back to their targets and regain function. This requires the axons to navigate through two different environments.(1) The bridge of new tissue that forms between the two nerve stumps and (2) the distal stump of the nerve that remains associated with the target tissues. This involves distinct, complex multicellular responses that guide and sustain axonal regrowth. These processes have important implications for our understanding of the regeneration of an adult tissue and have parallels to aspects of tumour formation and spread.
Elsevier