ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
Y Hu, GK Smyth - Journal of immunological methods, 2009 - Elsevier
ELDA is a software application for limiting dilution analysis (LDA), with particular attention to
the needs of stem cell assays. It is the first limiting dilution analysis software to provide
meaningful confidence intervals for all LDA data sets, including those with 0% or 100%
responses. Other features include a test of the adequacy of the single-hit hypothesis, tests
for frequency differences between multiple data sets, and the ability to take advantage of
cases where the number of cells in the sample is counted exactly. A webtool at http://bioinf …
the needs of stem cell assays. It is the first limiting dilution analysis software to provide
meaningful confidence intervals for all LDA data sets, including those with 0% or 100%
responses. Other features include a test of the adequacy of the single-hit hypothesis, tests
for frequency differences between multiple data sets, and the ability to take advantage of
cases where the number of cells in the sample is counted exactly. A webtool at http://bioinf …