[HTML][HTML] Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein …
The innate immune system protects the host from bacterial and viral invasion. Surfactant
protein A (SPA), a lung-specific collectin, stimulates macrophage chemotaxis. However, the
mechanisms regulating this function are unknown. Hyaluronan (HA) and its receptors
RHAMM (receptor for HA-mediated motility, CD168) and CD44 also regulate cell migration
and inflammation. We therefore examined the role of HA, RHAMM, and CD44 in SPA-
stimulated macrophage chemotaxis. Using antibody blockade and murine macrophages …
protein A (SPA), a lung-specific collectin, stimulates macrophage chemotaxis. However, the
mechanisms regulating this function are unknown. Hyaluronan (HA) and its receptors
RHAMM (receptor for HA-mediated motility, CD168) and CD44 also regulate cell migration
and inflammation. We therefore examined the role of HA, RHAMM, and CD44 in SPA-
stimulated macrophage chemotaxis. Using antibody blockade and murine macrophages …