[HTML][HTML] Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway
K Park, PM Elias, Y Oda, D Mackenzie, T Mauro… - Journal of Biological …, 2011 - ASBMB
Vitamin D receptor (VDR)-dependent mechanisms regulate human cathelicidin antimicrobial
peptide (CAMP)/LL-37 in various cell types, but CAMP expression also increases after
external perturbations (such as infection, injuries, UV irradiation, and permeability barrier
disruption) in parallel with induction of endoplasmic reticulum (ER) stress. We demonstrate
that CAMP mRNA and protein expression increase in epithelial cells (human primary
keratinocytes, HaCaT keratinocytes, and HeLa cells), but not in myeloid (U937 and HL-60) …
peptide (CAMP)/LL-37 in various cell types, but CAMP expression also increases after
external perturbations (such as infection, injuries, UV irradiation, and permeability barrier
disruption) in parallel with induction of endoplasmic reticulum (ER) stress. We demonstrate
that CAMP mRNA and protein expression increase in epithelial cells (human primary
keratinocytes, HaCaT keratinocytes, and HeLa cells), but not in myeloid (U937 and HL-60) …