Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8+ regulatory T cells

V Le Guen, JP Judor, F Boeffard, V Gauttier, N Ferry… - Journal of …, 2017 - Elsevier
Background & Aims Induction of donor-specific immune tolerance is a good alternative to
chronic life-long immunosuppression for transplant patients. Donor major histocompatibility
complex (MHC) molecules represent the main targets of the allogeneic immune response of
transplant recipients. Liver targeted gene transfer with viral vectors induces tolerance toward
the encoded antigen. The aim of this work was to determine whether alloantigen gene
transfer to hepatocytes induces tolerance and promotes graft acceptance. Methods C57BL/6 …