[HTML][HTML] Ectodomain shedding and autocleavage of the cardiac membrane protease corin
J Jiang, S Wu, W Wang, S Chen, J Peng… - Journal of Biological …, 2011 - ASBMB
Corin is a cardiac membrane protease that activates natriuretic peptides. It is unknown how
corin function is regulated. Recently, soluble corin was detected in human plasma,
suggesting that corin may be shed from cardiomyocytes. Here we examined soluble corin
production and activity and determined the proteolytic enzymes responsible for corin
cleavage. We expressed human corin in HEK 293 cells and detected three soluble
fragments of∼ 180,∼ 160, and∼ 100 kDa, respectively, in the cultured medium by Western …
corin function is regulated. Recently, soluble corin was detected in human plasma,
suggesting that corin may be shed from cardiomyocytes. Here we examined soluble corin
production and activity and determined the proteolytic enzymes responsible for corin
cleavage. We expressed human corin in HEK 293 cells and detected three soluble
fragments of∼ 180,∼ 160, and∼ 100 kDa, respectively, in the cultured medium by Western …