[HTML][HTML] Corin mutations K317E and S472G from preeclamptic patients alert zymogen activation and cell surface targeting
N Dong, T Zhou, Y Zhang, M Liu, H Li, X Huang… - Journal of Biological …, 2014 - ASBMB
Corin is a membrane-bound serine protease that acts as the atrial natriuretic peptide (ANP)
convertase in the heart. Recent studies show that corin also activates ANP in the pregnant
uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension.
Two CORIN gene mutations, K317E and S472G, were identified in preeclamptic patients
and shown to have reduced activity in vitro. In this study, we carried out molecular modeling
and biochemical experiments to understand how these mutations impair corin function. By …
convertase in the heart. Recent studies show that corin also activates ANP in the pregnant
uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension.
Two CORIN gene mutations, K317E and S472G, were identified in preeclamptic patients
and shown to have reduced activity in vitro. In this study, we carried out molecular modeling
and biochemical experiments to understand how these mutations impair corin function. By …