APOL1 G2 risk allele—clarifying nomenclature
To the Editor: Several publications have reported APOL1 variants (G1 and G2) to be
associated with kidney diseases, including focal segmental glomerulosclerosis, HIV-
associated nephropathy, and nondiabetic end-stage renal disease, 1 as well as kidney
allograft survival. 2 The G1 and G2 risk alleles in APOL1 are prevalent in African populations
and admixed populations with an African ancestry component. 1 The G1 allele is defined by
rs73885319 (p. S342G) and rs60910145 (p. I384M), 2 missense single-nucleotide …
associated with kidney diseases, including focal segmental glomerulosclerosis, HIV-
associated nephropathy, and nondiabetic end-stage renal disease, 1 as well as kidney
allograft survival. 2 The G1 and G2 risk alleles in APOL1 are prevalent in African populations
and admixed populations with an African ancestry component. 1 The G1 allele is defined by
rs73885319 (p. S342G) and rs60910145 (p. I384M), 2 missense single-nucleotide …