[HTML][HTML] Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93fes, STAT1 p91, and STAT3 p92 in …
MF Brizzi, MG Aronica, A Rosso, GP Bagnara… - Journal of Biological …, 1996 - ASBMB
Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation,
differentiation, and functional activation of hemopoietic cells by its interaction with a
heterodimeric receptor. Although GM-CSF receptor is devoid of tyrosine kinase enzymatic
activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional
activation is mediated by the phosphorylation of a large number of intracellular signaling
molecules. We have previously shown that JAK2 becomes tyrosine-phosphorylated in …
differentiation, and functional activation of hemopoietic cells by its interaction with a
heterodimeric receptor. Although GM-CSF receptor is devoid of tyrosine kinase enzymatic
activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional
activation is mediated by the phosphorylation of a large number of intracellular signaling
molecules. We have previously shown that JAK2 becomes tyrosine-phosphorylated in …