[HTML][HTML] Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils: selective activation of Jak2, Stat3, and Stat5b
A Al-Shami, W Mahanna, PH Naccache - Journal of Biological Chemistry, 1998 - ASBMB
Granulocyte-macrophage colony stimulating factor (GM-CSF) regulates many of the
biological functions of human neutrophils. This includes the stimulation of protein synthesis
and the tyrosine phosphorylation of various proteins among which is JAK2. The present
study was aimed at characterizing in detail the pattern of activation by GM-CSF of the
JAK/STAT pathway in human neutrophils. The results obtained show that the stimulation of
human neutrophils by GM-CSF specifically led to tyrosine phosphorylation of JAK2 and had …
biological functions of human neutrophils. This includes the stimulation of protein synthesis
and the tyrosine phosphorylation of various proteins among which is JAK2. The present
study was aimed at characterizing in detail the pattern of activation by GM-CSF of the
JAK/STAT pathway in human neutrophils. The results obtained show that the stimulation of
human neutrophils by GM-CSF specifically led to tyrosine phosphorylation of JAK2 and had …