[HTML][HTML] Column-switching HPLC for the analysis of plasma in PET imaging studies
J Hilton, F Yokoi, RF Dannals, HT Ravert… - Nuclear medicine and …, 2000 - Elsevier
A column-switch high performance liquid chromatography method for the analysis of 4 mL of
plasma is described with six examples of chromatography of [11C]-labeled positron-
emission tomography imaging agents. Complete extraction of all but the most polar
metabolites by the reverse phase capture column is achieved by disruption of plasma
protein binding by 8 M urea.
plasma is described with six examples of chromatography of [11C]-labeled positron-
emission tomography imaging agents. Complete extraction of all but the most polar
metabolites by the reverse phase capture column is achieved by disruption of plasma
protein binding by 8 M urea.