Association between elevated brain amyloid and subsequent cognitive decline among cognitively normal persons
MC Donohue, RA Sperling, R Petersen, CK Sun… - Jama, 2017 - jamanetwork.com
Importance Among cognitively normal individuals, elevated brain amyloid (defined by
cerebrospinal fluid assays or positron emission tomography regional summaries) can be
related to risk for later Alzheimer-related cognitive decline. Objective To characterize and
quantify the risk for Alzheimer-related cognitive decline among cognitively normal
individuals with elevated brain amyloid. Design, Setting, and Participants Exploratory
analyses were conducted with longitudinal cognitive and biomarker data from 445 …
cerebrospinal fluid assays or positron emission tomography regional summaries) can be
related to risk for later Alzheimer-related cognitive decline. Objective To characterize and
quantify the risk for Alzheimer-related cognitive decline among cognitively normal
individuals with elevated brain amyloid. Design, Setting, and Participants Exploratory
analyses were conducted with longitudinal cognitive and biomarker data from 445 …