[HTML][HTML] Circadian and sleep dysfunctions in neurodegenerative disorders—An update
K Fifel, A Videnovic - Frontiers in Neuroscience, 2021 - frontiersin.org
Frontiers in Neuroscience, 2021•frontiersin.org
Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered
and multifactorial. Recent evidence suggests that sleep and circadian disturbances may
influence the neurodegenerative processes as well as be their consequence. In this
perspective, we provide an update of the current understanding of sleep and circadian
dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered
and multifactorial. Recent evidence suggests that sleep and circadian disturbances may
influence the neurodegenerative processes as well as be their consequence. In this
perspective, we provide an update of the current understanding of sleep and circadian
dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.
Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer’s, Parkinson’s, and Huntington’s diseases.
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