Importance Disruption in circadian activity rhythms is very common in older adults,
particularly among those with neurodegenerative diseases, including Parkinson disease
(PD). However, whether circadian disruption could be a prodrome for PD is unclear.
Objective To determine the association between rest-activity rhythm (RAR) and risk of
incident PD and to explore whether this association is independent of nighttime sleep
disturbances. Design, Setting, and Participants The ancillary sleep study of the longitudinal …