Circadian clock gene Period2 regulates a time-of-day–dependent variation in cutaneous anaphylactic reaction
Y Nakamura, D Harama, N Shimokawa, M Hara… - Journal of allergy and …, 2011 - Elsevier
Background IgE-mediated immediate-type skin reaction shows a diurnal rhythm, although
the precise mechanisms remain uncertain. Period2 (Per2) is a key circadian gene that is
essential for endogenous clockworks in mammals. Objective This study investigated
whether Per2 regulates a time-of-day–dependent variation in IgE-mediated immediate-type
skin reaction. Methods The kinetics of a passive cutaneous anaphylactic reaction were
compared between wild-type mice and mice with a loss-of-function mutation of Per2 (mPer2 …
the precise mechanisms remain uncertain. Period2 (Per2) is a key circadian gene that is
essential for endogenous clockworks in mammals. Objective This study investigated
whether Per2 regulates a time-of-day–dependent variation in IgE-mediated immediate-type
skin reaction. Methods The kinetics of a passive cutaneous anaphylactic reaction were
compared between wild-type mice and mice with a loss-of-function mutation of Per2 (mPer2 …