The association of pediatric obesity with nocturnal non-dipping on 24-hour ambulatory blood pressure monitoring
IR Macumber, NS Weiss, SM Halbach… - American journal of …, 2016 - academic.oup.com
IR Macumber, NS Weiss, SM Halbach, CD Hanevold, JT Flynn
American journal of hypertension, 2016•academic.oup.comBACKGROUND Obesity has been linked with abnormal nocturnal dipping of blood pressure
(BP) in adults, which in turn is associated with poor cardiovascular outcomes. There are few
data regarding abnormal dipping status in the obese pediatric population. The goal of this
study was to further describe the relationship between obesity and non-dipping status on
ambulatory blood pressure monitor (ABPM) in children. METHODS We conducted a cross-
sectional study using a database of patients aged 5–21 years who had undergone 24-hour …
(BP) in adults, which in turn is associated with poor cardiovascular outcomes. There are few
data regarding abnormal dipping status in the obese pediatric population. The goal of this
study was to further describe the relationship between obesity and non-dipping status on
ambulatory blood pressure monitor (ABPM) in children. METHODS We conducted a cross-
sectional study using a database of patients aged 5–21 years who had undergone 24-hour …
BACKGROUND
Obesity has been linked with abnormal nocturnal dipping of blood pressure (BP) in adults, which in turn is associated with poor cardiovascular outcomes. There are few data regarding abnormal dipping status in the obese pediatric population. The goal of this study was to further describe the relationship between obesity and non-dipping status on ambulatory blood pressure monitor (ABPM) in children.
METHODS
We conducted a cross-sectional study using a database of patients aged 5–21 years who had undergone 24-hour ABPM at Seattle Children’s Hospital from January 2008 through May 2014. Subjects were grouped by body mass index (BMI) into lean (BMI 15th–85th percentile) and obese (BMI >95th percentile) groups.
RESULTS
Compared to lean subjects ( n = 161), obese subjects ( n = 247) had a prevalence ratio (PR) for non-dipping of 2.15, adjusted for race (95% confidence interval (CI) = 1.25–3.42). Increasing severity of obesity was not further associated with nocturnal non-dipping. Nocturnal non-dipping was not associated with left ventricular hypertrophy (PR = 1.01, 95% CI = 0.71–1.44).
CONCLUSIONS
These results suggest that in children, just as in adults, obesity is related to a relatively decreased dipping in nocturnal BP.
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