APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy
N Papeta, K Kiryluk, A Patel, R Sterken… - Journal of the …, 2011 - journals.lww.com
A chromosome 22q13 locus strongly associates with increased risk for idiopathic focal
segmental glomerulosclerosis (FSGS), HIV-1-associated nephropathy (HIVAN), and
hypertensive ESRD among individuals of African descent. Although initial studies implicated
MYH9, more recent analyses localized the strongest association within the neighboring
APOL1 gene. In this replication study, we examined the six top-most associated variants in
APOL1 and MYH9 in an independent cohort of African Americans with various …
segmental glomerulosclerosis (FSGS), HIV-1-associated nephropathy (HIVAN), and
hypertensive ESRD among individuals of African descent. Although initial studies implicated
MYH9, more recent analyses localized the strongest association within the neighboring
APOL1 gene. In this replication study, we examined the six top-most associated variants in
APOL1 and MYH9 in an independent cohort of African Americans with various …