A simple diet-and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer
T Tsuchida, YA Lee, N Fujiwara, M Ybanez, B Allen… - Journal of …, 2018 - Elsevier
Background and Aims Although the majority of patients with non-alcoholic fatty liver disease
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic
steatohepatitis (NASH), which can lead to cirrhosis and hepatocellular carcinoma (HCC).
Many established diet-induced mouse models for NASH require 24–52 weeks, which makes
testing for drug response costly and time consuming. Methods We have sought to establish
a murine NASH model with rapid progression of extensive fibrosis and HCC by using a …
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic
steatohepatitis (NASH), which can lead to cirrhosis and hepatocellular carcinoma (HCC).
Many established diet-induced mouse models for NASH require 24–52 weeks, which makes
testing for drug response costly and time consuming. Methods We have sought to establish
a murine NASH model with rapid progression of extensive fibrosis and HCC by using a …