[HTML][HTML] Identification of novel biomarkers for Behcet disease diagnosis using human proteome microarray approach
Behcet disease (BD) is a chronic systemic vasculitis and considered as an autoimmune
disease. Although rare, BD can be fatal due to ruptured vascular aneurysms or severe
neurological complications. To date, no known biomarker has been reported for this
disease, making it difficult to diagnosis in the clinics. To undertake this challenge, we
employed the HuProt arrays, each comprised of∼ 20,000 unique human proteins, to identify
BD-specific autoantibodies using a Two-Phase strategy established previously. In Phase I …
disease. Although rare, BD can be fatal due to ruptured vascular aneurysms or severe
neurological complications. To date, no known biomarker has been reported for this
disease, making it difficult to diagnosis in the clinics. To undertake this challenge, we
employed the HuProt arrays, each comprised of∼ 20,000 unique human proteins, to identify
BD-specific autoantibodies using a Two-Phase strategy established previously. In Phase I …