[HTML][HTML] Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis
S Rosenkranz, KA DeMali, JA Gelderloos… - Journal of Biological …, 1999 - ASBMB
Activation of the platelet-derived growth factor (PDGF) α receptor (αPDGFR) leads to cell
migration and DNA synthesis. These events are preceded by the ligand-induced tyrosine
phosphorylation of the receptor and its association with SH2-containing signaling enzymes
including Src family members (Src), the phosphotyrosine phosphatase SHP-2,
phosphatidylinositol 3-kinase (PI3K), and phospholipase C-γ1 (PLCγ). In this study, we
sought to systematically evaluate the relative roles of the signaling enzymes that are …
migration and DNA synthesis. These events are preceded by the ligand-induced tyrosine
phosphorylation of the receptor and its association with SH2-containing signaling enzymes
including Src family members (Src), the phosphotyrosine phosphatase SHP-2,
phosphatidylinositol 3-kinase (PI3K), and phospholipase C-γ1 (PLCγ). In this study, we
sought to systematically evaluate the relative roles of the signaling enzymes that are …