[HTML][HTML] Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia
Vascular smooth muscle cell (VSMC) proliferation and migration contribute significantly to
atherosclerosis, postangioplasty restenosis, and transplant vasculopathy. Forkhead
transcription factors belonging to the FoxO subfamily have been shown to inhibit growth and
cell cycle progression in a variety of cell types. We hypothesized that forkhead proteins may
play a role in VSMC biology. Under in vitro conditions, platelet-derived growth factor (PDGF)-
BB, tumor necrosis factor-α, and insulin-like growth factor 1 stimulated phosphorylation of …
atherosclerosis, postangioplasty restenosis, and transplant vasculopathy. Forkhead
transcription factors belonging to the FoxO subfamily have been shown to inhibit growth and
cell cycle progression in a variety of cell types. We hypothesized that forkhead proteins may
play a role in VSMC biology. Under in vitro conditions, platelet-derived growth factor (PDGF)-
BB, tumor necrosis factor-α, and insulin-like growth factor 1 stimulated phosphorylation of …