The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling
J Wu, P Zhu, T Lu, Y Du, Y Wang, L He, B Ye, B Liu… - Journal of …, 2019 - Elsevier
Background & Aims Liver cancer is the second leading cause of cancer death worldwide.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults.
The aim of this study was to define the role of the long non-coding RNA lncHDAC2 in the
tumorigenesis of HCC. Methods CD13+ CD133+ cells (hereafter called liver cancer stem
cells [CSCs]) and CD13-CD133-cells (referred to as non-CSCs) were sorted from 3 primary
HCC tumor tissues and followed by transcriptome microarray. The expression and function …
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults.
The aim of this study was to define the role of the long non-coding RNA lncHDAC2 in the
tumorigenesis of HCC. Methods CD13+ CD133+ cells (hereafter called liver cancer stem
cells [CSCs]) and CD13-CD133-cells (referred to as non-CSCs) were sorted from 3 primary
HCC tumor tissues and followed by transcriptome microarray. The expression and function …